A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. The C57BL/6 inbred mouse (B6) is the most commonly used research strain. Examples of the developmental stages of albino, agouti, and black pups are shown. Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity. endobj 2004. 2003. Interferon is induced by viral infection and in turn induces the Mx protein (J:7703). endstream Others have subsequently identified further SNP differences between sublines of C57BL/6 (Mekada et al., 2009, Zurita et al., 2010). (2)The Jackson Laboratory, Bar Harbor, ME, USA. When using B6 mice it is very important to reference the full nomenclature that indicates its provenance and vendor code (eg, C57BL/6NTac from Taconic and C57BL/6J from The Jackson Laboratory). application/pdf Therefore, we cannot guarantee a strain's phenotype will meet all expectations. C57BL/6J (B6), B6.C-H-2bm12/KhEg (bm12), and C57BL/6J ApoE knockout (B6ApoE-/-) mice were originally obtained from The Jackson Laboratory (Bar Harbor, ME).B6ApoE-/-mice were backcrossed to C57BL/6J-lpr/lpr (B6/lpr) for four generations, and to MRL/MpJ-Fas lpr (MRL/lpr) for ten generations. To Hall in 1948 from The Jackson Laboratory. Strains 6 and 10 separated about 1937. Watch Video. The mutation lies within a C-terminal cytoplasmic domain homologous with the TNFR 1-death domain and with an SH3 binding protein. 1996. Thank you for sharing your feedback! Animals were maintained in a 16 h light-8 h dark cycle, at 20 ± 2 °C, with food and water ad libitum. 7 0 obj Researchers from The Jackson Laboratory sent 40 mice to the ISS National Lab, including some “Mighty Mice” that lack the gene for producing the growth factor myostatin. endobj The approximate age of mouse pups can be determined by their physical attributes during the irst two weeks of life. This strain is the most well characterized, the first to have its’ entire genome sequenced, and is the genetic background strai . Sci Rep 6:36579, Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. 27 0 obj Metabolism 47(9):1089-96, Parham K. 1997. 6 0 obj <>stream Sgpl1 ± mice were obtained from Jackson Laboratory, and then, these mice were bred to generate Sgpl1 +/+ and Sgpl1 ‐/‐ littermates. / endstream Diabetes 55(7):2153-6, Hollyfield JG; Bonilha VL; Rayborn ME; Yang X; Shadrach KG; Lu L; Ufret RL; Salomon RG; Perez VL. 14 0 obj 1994. 2008. Histol Histopathol 15(4):1087-92, Chen J; Astle CM; Harrison DE. Developed by C.C. x�S�*�*T0T0 B�����i������ y8# However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Nat Commun 7:13180, Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. Cell 71(7):1195-204, Cernuda-Cernuda R; Huerta JJ; Munoz Llamosas M; Alvarez-Uria M; Garcia-Fernandez JM. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Unstable FoxP3+ T regulatory cells in NZW mice. <>>>/BBox[0 0 585 783]/Length 114>>stream To NIH in 1951 from The Jackson Laboratory at F32. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings. Readily available in any quantity needed. 1993. Mice Pup Appearance by Age. Quantities: Volume pricing is automatically applied when a minimum quantity per strain for a shipment is reached endstream Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. 4 0 obj Genetic differences among C57BL/6 substrains. 1992. 19 0 obj x�+� � | Overall, C57BL/6J mice breed well, are long-lived, and have a low susceptibility to tumors. Mice derived from Jackson Laboratory can be used within KU without additional cost. Transgenic Res 20(3):481-9. Susceptibility alleles do not produce the protein (J:8273). Both C57BL/6ByJ and C57BL/6NJ type as follows: 08-015199792-M (rs3709624) is C; 11-004367508-M (rs3659787) is A; 13-041017317-M (rs3722313) is C; 15-057561875-M (rs3702158) is G; 19-049914266-M (rs3724876) is T. C57BL/6J types as follows: 08-015199792-M (rs3709624) is T; 11-004367508-M (rs3659787) is G; 13-041017317-M (rs3722313) is T; 15-057561875-M (rs3702158) is A; 19-049914266-M (rs3724876) is G (Petkov and Wiles, 2004.) x�%�A�@�}O�(��'.�r�^���� Arteriosclerosis 10(2):316-23, Parekh PI; Petro AE; Tiller JM; Feinglos MN; Surwit RS. Science 345(6195):455-9, Jackson IL; Zhang Y; Bentzen SM; Hu J; Zhang A; Vujaskovic Z. Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. The Jackson Laboratory (JAX)® advocates adherence to the mouse strain nomenclature guidelines as described by the International Committee on Standardized Genetic Nomenclature for Mice. Distortion product otoacoustic emissions in the C57BL/6J mouse model of age-related hearing loss. 1998. This widely used … Macrophages from this strain are resistant to the effects of anthrax lethal toxin.Study-ready aged C57BL/6J males and females between 25 - 90 weeks of age available for order. B6.Cg-Tg(Alb-Cre)21Mgn/J. The protein is located in the nucleus (J:7703) and produces its antiviral effect by preventing synthesis of viral mRNA in the nucleus (J:7992). Genome Res 14(9):1806-11, Roberts JE; Watters JW; Ballard JD; Dietrich WF. Two animals of the same strain and sex, aged 10 weeks, were introduced into a novel open-field for 10 min. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805, Smith RS; Roderick TH; Sundberg JP. This variant is found in AKR/J, C3H/HeJ, C57BL/6, C57BL/10, CBA/J, DBA/1, DBA/2, FVB/NJ, and NZO/HILtJ. Th ey are safe, reliable, economical, effi cient, and ensure that endstream One of the unique advantages to working with mice, rather than other experimental organisms, is the availability of standard strains such as C57BL/6 (abbreviated B6), BALB/c, and many others that are used in thousands of laboratories around the world each year. A substantial proportion of these mice exhibit seizure activity. 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Species: Mouse Genes: MAPT Mutations: MAPT P301S Modification: MAPT: Transgenic Disease Relevance: Alzheimer's Disease, Frontotemporal Dementia Strain Name: B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J Genetic Background: (C57BL/6 x C3H)F1 Availability: The Jackson Lab: Stock# 008169; Live.Research with this model is available from QPS Austria.. Summary. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Hear Res 112(1-2):216-34, Petkov PM; Ding Y; Cassell MA; Zhang W; Wagner G; Sargent EE; Asquith S; Crew V; Johnson KA; Robinson P; Scott VE; Wiles MV. Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years. Since C57BL/6JEi separated from C57BL/6J in 1976, the Nnt deletion arose sometime between 1976 and 1984. proof:pdf 10 0 obj endstream To Charles River in 1974 from NIH. from application/x-indesign to application/pdf Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus). 45:29 9 months ago Designing & Optimizing Mouse Breeding Schemes Watch this video to get a refresher on the fundamentals of basic mouse genetics and learn some tricks from our experts to plan your next experiment better. For more information, see the Worldwide Distributor List for JAX® Mice. 1995. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. 2000. We may wish to follow up with you. B6.Rag1-/- mice displayed nearly identical blood pressure increases monitored via radiotelemetry and hypertensive end-organ damage in response to different doses of Ang II and different levels of salt intake (0.02%, 0.3%, and 3% NaCl diet). This allele confers increased forebrain weight compared to DBA/2J. 2000. This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age. This is predicted to delete part of the 2nd and 3rd ectodomains and cause reduced message stability. Immunogenetics 61(3):199-207, Zurita E; Chagoyen M; Cantero M; Alonso R; Gonzalez-Neira A; Lopez-Jimenez A; Lopez-Moreno JA; Landel CP; Benitez J; Pazos F; Montoliu L. 2011. To NIH in 1951 from The Jackson Laboratory at F32. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. Mice. Further analysis has shown this is caused by a G to A transition at coding nucleotide position 753 of Cdh23 (SNP rs257098870).
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