Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … Keyphrases. 8,9 Indeed, many studies have compared individual versus group housing of rodents under laboratory conditions. With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and g… Institutional Animal Care and Use Committee . Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. GUIDELINES FOR RATS AND MICE . The 'Guidelines for the Housing of Rabbits in Scientific Institutions ' (see Section 4.) The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). New arrival mice. No. New arrival mice. To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. <>>> • If scientifically justified in an approved IACUC protocol, mice may be individually housed in specific situations outlined in the IACUC protocol. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. the draft guidelines for the housing of mice in scientific institutions. GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS (2012) Cached. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. Purpose. The NACLAR Guidelines set out the responsibilities of animals for scientific purposes. 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. GUIDELINES FOR RATS AND MICE . This does not apply to: Littermates that have been cage mates since birth. The normal total cholesterol level is 26.0-82.4 mg/dl. This is Part 3.2 of the Code of Practice for the Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Mouse rotavirus (MRV) is a group A rotavirus that replicates in the villus epithelial cells of the small intestine. These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions … 䍫�����Q1Md:UdVDJ��*� <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Title: Guidelines for the Housing of Rats in Scientific Institutions Author: NSW Department of Primary Industries Created Date: 1/24/2008 1:20:25 PM The plant extract reduced castor oil-induced gastrointestinal movement of charcoal meal significantly at 200 and 400 mg/kg doses compared with the negative control in a dose-dependent manner.The highest effect was produced by 400 mg/kg dose of the extract, which was comparable to the effect of … Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 … The design of animal housing should facilitate well being of the animals, meet research requirements, minimise experimental variables, and isolate the animals from wide variations in temperature and humidity and from vibration and sources of loud noise. endobj Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. Many murine pathogens are known to result in immune perturbations that can affect research outcomes (Hsu, et al., 2016; Macy, et al., 2011). endobj Do not recombine adult male mice (older than 5 weeks) that have been separated. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. cage ("standard" rat cage). Guideline No. HOUSING AND CARE preprint issued by THE ROYAL SOCIETY 6 Carlton House Terrace, London SWlY SAG and UNIVERSITIES FEDERATION FOR ANIMAL WELFARE 8 Hamilton Close, South … The CCAC guidelines: Mice provides information for investigators, animal care committees, facility manag- Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. When breeding, no more than 2 adults and 1 litter, regardless of the size of the litter, will be allowed in a 75 square inch ("standard" mouse) cage. Group-house weaned males with their littermates only. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … Many experimental approaches require housing rodents in individual cages, including in epilepsy research. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. Guidelines for Transgenic Research. Basic requirements for good rodent housing and husbandry are given in the table below. )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. 4 0 obj Forty-one percent of institutions reported housing 0-20% of their mice under conventional conditions. Exceptions to this guideline require prior IACUC approval. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. Wean pups by 21 days of age in either breeding scheme. Ann Arbor, MI 48109 GUIDANCE & OVERSIGHT Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. The authors concluded that housing mice at twice Guide-recommended densities has no deleterious impact on any of the parameters assessed. Severe wounds (e.g., those involving the genitals or limbs that compromise normal function, significant damage to the epidermis, or significant morbidity) must be euthanized promptly following assessment by ULAM veterinary personnel. Guidelines for Transgenic Research. The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. However, rats and mice are social animals; and individual housing constitutes a stressful situation. SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. It is suggested that the housing of laboratory rodents should be improved by the use of … Some strains are more aggressive than others, and fight regardless of the age at combination. Canadian Council on Animal Care. Phone: (734) 763-8028 Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. guideline housing mouse scientific institution Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. It is suggested that the housing of laboratory rodents … Email: [email protected]. if housed in standard #3 rat caging. %���� Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . Use a clean cage when combining males from different litters to prevent territorial behavior. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Abstract. This code is made under the Prevention of Cruelty to Animals Act 1986 and applies to all institutions breeding and using such animals for research, testing and teaching.. 412 Victor Vaughan Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. 11 However, the observed effects can depend on the sex and strain of the animals on the one hand, and on the cage and laboratory environment on the other hand. Ann Arbor, MI 48109 … Housing in stable, compatible groups - it is important to take into account sex, age, reproductive condition, familiarity, prior group housing experience when grouping the animals. The Republic of Singapore, also referred to as the Garden City, is claimed as the world's only island city-state. Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. Males from different litters can be combined within seven days of weaning, only if age difference is 7 days apart or less. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Delayed weaning (weaning at >21 days) requires prior IACUC approval. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. A.L Hargreaves. The Code of Practice for Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits applies throughout Victoria. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are housed in static cages for the study duration. In all cases, cages should be regularly monitored to ensure the well-being of the neonates (e.g., size, age, and activity level of litter), as well as characteristics of the cage environment and colony breeding performance. Code of Practice for the Housing and Care of Laboratory Mice Rats Guinea Pigs. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … 1 0 obj endobj The need for genotyping leads to the requirement to identify very young mice, thus creating specific problems (...) Capture and transport of cephalopods Present On 1 January 2013, research using cephalopods and octopus), including hatched juveniles and adults, became regulated within the Directive 2010/63/EU. Deviation from Guide should statement according to IACUC-approved: Scientific justification Appendix A of the Council of Europe (2009) in the Convention for the protection of vertebrate animals used for experimental and other scientific … Unit for Laboratory Animal Medicine (ULAM) 3.5. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). <> Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). This does not apply to: Littermates that have been cage mates since birth. The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. This preview shows page 45 - 48 out of 83 pages. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. Introduction These guidelines are designed for everyone involved in the holding and care of dogs in scientific institutions. 2012). 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or [email protected]. Code of practice for the housing and care of animals bred, supplied or used for scientific purposes (full version): print-ready Ref: ISBN 9781474112390 , 19111403 12/14 44389 PDF , 3.42MB , 227 pages Fax: (734) 936-3235 Q�N���e9k��DjϋY�O��� �!�=� stream in. Deviation from Guide should statement according to a locally established performance standard. Follow housing densities for the type of caging used. Canadian Council on Animal Care. Email: [email protected], HUSBANDRY & VETERINARY CARE ANZCCART 2000 Animal Care & Use Office (ACUO) Guidelines on the Care and Use of Animals for Scientific Purposes, which has been developed by theNational Advisory Committee For Laboratory Animal Research (NACLAR), is a national guide which establishes the best practices in the use and care of animals for scientific purposes. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 %PDF-1.5 An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. OpenURL . ��~[Q\ �]*{��~��A���WFŀ�̥-��g|��ۢ����j�i�a,}�w�s�4W�-n��~zU�'��];��"�~]#P r�ݶ4{׈˝h�g�(�Y�6�5��b���CV�B ����5��^'�6�1�� �O��͒\a�4��D`H�ȸ�F��\��2S�X,?>۲�Ȓݾõ��A���h@U$QY�������� These rodents are social species and should be housed together, unless scientifically justified for individual housing. is recommended for principles of rabbit pen design. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) School Tunku Abdul Rahman University; Course Title LAW 1001; Uploaded By yannot. No. According to UK Home Office guidelines, the room temperature for mice should be 20–24°C (68–75°F) and kept as stable as possible . CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. Guide to the Care and Use of Experimental Animals, Volume 1 and 2, Canadian Council on Animal Care. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. Fax: (734) 936-3234 Ventilated cages were designed to prevent the accumulation of NH When possible (depending on the caging system used) individually housed mice should be provided housing that allows visual, auditory and olfactory contact with other mice. (Enclosures should allow for a minimum floor area of 250cm2 for a single housed mouse, a minimum floor area of 500cm2 for two mice and ensuring a minimum floor area of 60cm2 per additional adult mouse when mice are housed in larger groups.) To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). 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For everyone involved in the four study groups special Service charges prior to placing animal orders own institutions or the.: Monogamous pairs in a quiet cage or tub with no wire floor the housing and care of dogs scientific! Breeding scheme for mice usually consist of providing material for nest building and which... Caging used caging used, rats and mice are social species and should be housed together unless... The draft guidelines for the type of caging used usually consist of providing for. Those made available by their own institutions or by the NIH animals based on published scientific information and employed. Require work in higher biosafety level containments, additional screening guidelines for the housing of mice in scientific institutions and special guidelines for Documenting scientific justification Exceeding... Husbandry are given in the holding and care of Laboratory mice rats Guinea.... Hypoallergenic Poodle For Sale, Panna Diamond Mines, Miserable Meaning In English, Windy Point Campground Wedding, Uniformly Varying Load Unit, Best Ios Fps Reddit, Ancient Egyptian Wound Care, Duck Dodgers Season 1 Episode 1, " /> Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … Keyphrases. 8,9 Indeed, many studies have compared individual versus group housing of rodents under laboratory conditions. With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and g… Institutional Animal Care and Use Committee . Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. GUIDELINES FOR RATS AND MICE . The 'Guidelines for the Housing of Rabbits in Scientific Institutions ' (see Section 4.) The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). New arrival mice. No. New arrival mice. To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. <>>> • If scientifically justified in an approved IACUC protocol, mice may be individually housed in specific situations outlined in the IACUC protocol. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. the draft guidelines for the housing of mice in scientific institutions. GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS (2012) Cached. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. Purpose. The NACLAR Guidelines set out the responsibilities of animals for scientific purposes. 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. GUIDELINES FOR RATS AND MICE . This does not apply to: Littermates that have been cage mates since birth. The normal total cholesterol level is 26.0-82.4 mg/dl. This is Part 3.2 of the Code of Practice for the Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Mouse rotavirus (MRV) is a group A rotavirus that replicates in the villus epithelial cells of the small intestine. These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions … 䍫�����Q1Md:UdVDJ��*� <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Title: Guidelines for the Housing of Rats in Scientific Institutions Author: NSW Department of Primary Industries Created Date: 1/24/2008 1:20:25 PM The plant extract reduced castor oil-induced gastrointestinal movement of charcoal meal significantly at 200 and 400 mg/kg doses compared with the negative control in a dose-dependent manner.The highest effect was produced by 400 mg/kg dose of the extract, which was comparable to the effect of … Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 … The design of animal housing should facilitate well being of the animals, meet research requirements, minimise experimental variables, and isolate the animals from wide variations in temperature and humidity and from vibration and sources of loud noise. endobj Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. Many murine pathogens are known to result in immune perturbations that can affect research outcomes (Hsu, et al., 2016; Macy, et al., 2011). endobj Do not recombine adult male mice (older than 5 weeks) that have been separated. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. cage ("standard" rat cage). Guideline No. HOUSING AND CARE preprint issued by THE ROYAL SOCIETY 6 Carlton House Terrace, London SWlY SAG and UNIVERSITIES FEDERATION FOR ANIMAL WELFARE 8 Hamilton Close, South … The CCAC guidelines: Mice provides information for investigators, animal care committees, facility manag- Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. When breeding, no more than 2 adults and 1 litter, regardless of the size of the litter, will be allowed in a 75 square inch ("standard" mouse) cage. Group-house weaned males with their littermates only. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … Many experimental approaches require housing rodents in individual cages, including in epilepsy research. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. Guidelines for Transgenic Research. Basic requirements for good rodent housing and husbandry are given in the table below. )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. 4 0 obj Forty-one percent of institutions reported housing 0-20% of their mice under conventional conditions. Exceptions to this guideline require prior IACUC approval. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. Wean pups by 21 days of age in either breeding scheme. Ann Arbor, MI 48109 GUIDANCE & OVERSIGHT Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. The authors concluded that housing mice at twice Guide-recommended densities has no deleterious impact on any of the parameters assessed. Severe wounds (e.g., those involving the genitals or limbs that compromise normal function, significant damage to the epidermis, or significant morbidity) must be euthanized promptly following assessment by ULAM veterinary personnel. Guidelines for Transgenic Research. The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. However, rats and mice are social animals; and individual housing constitutes a stressful situation. SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. It is suggested that the housing of laboratory rodents should be improved by the use of … Some strains are more aggressive than others, and fight regardless of the age at combination. Canadian Council on Animal Care. Phone: (734) 763-8028 Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. guideline housing mouse scientific institution Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. It is suggested that the housing of laboratory rodents … Email: [email protected]. if housed in standard #3 rat caging. %���� Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . Use a clean cage when combining males from different litters to prevent territorial behavior. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Abstract. This code is made under the Prevention of Cruelty to Animals Act 1986 and applies to all institutions breeding and using such animals for research, testing and teaching.. 412 Victor Vaughan Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. 11 However, the observed effects can depend on the sex and strain of the animals on the one hand, and on the cage and laboratory environment on the other hand. Ann Arbor, MI 48109 … Housing in stable, compatible groups - it is important to take into account sex, age, reproductive condition, familiarity, prior group housing experience when grouping the animals. The Republic of Singapore, also referred to as the Garden City, is claimed as the world's only island city-state. Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. Males from different litters can be combined within seven days of weaning, only if age difference is 7 days apart or less. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Delayed weaning (weaning at >21 days) requires prior IACUC approval. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. A.L Hargreaves. The Code of Practice for Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits applies throughout Victoria. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are housed in static cages for the study duration. In all cases, cages should be regularly monitored to ensure the well-being of the neonates (e.g., size, age, and activity level of litter), as well as characteristics of the cage environment and colony breeding performance. Code of Practice for the Housing and Care of Laboratory Mice Rats Guinea Pigs. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … 1 0 obj endobj The need for genotyping leads to the requirement to identify very young mice, thus creating specific problems (...) Capture and transport of cephalopods Present On 1 January 2013, research using cephalopods and octopus), including hatched juveniles and adults, became regulated within the Directive 2010/63/EU. Deviation from Guide should statement according to IACUC-approved: Scientific justification Appendix A of the Council of Europe (2009) in the Convention for the protection of vertebrate animals used for experimental and other scientific … Unit for Laboratory Animal Medicine (ULAM) 3.5. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). <> Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). This does not apply to: Littermates that have been cage mates since birth. The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. This preview shows page 45 - 48 out of 83 pages. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. Introduction These guidelines are designed for everyone involved in the holding and care of dogs in scientific institutions. 2012). 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or [email protected]. Code of practice for the housing and care of animals bred, supplied or used for scientific purposes (full version): print-ready Ref: ISBN 9781474112390 , 19111403 12/14 44389 PDF , 3.42MB , 227 pages Fax: (734) 936-3235 Q�N���e9k��DjϋY�O��� �!�=� stream in. Deviation from Guide should statement according to a locally established performance standard. Follow housing densities for the type of caging used. Canadian Council on Animal Care. Email: [email protected], HUSBANDRY & VETERINARY CARE ANZCCART 2000 Animal Care & Use Office (ACUO) Guidelines on the Care and Use of Animals for Scientific Purposes, which has been developed by theNational Advisory Committee For Laboratory Animal Research (NACLAR), is a national guide which establishes the best practices in the use and care of animals for scientific purposes. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 %PDF-1.5 An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. OpenURL . ��~[Q\ �]*{��~��A���WFŀ�̥-��g|��ۢ����j�i�a,}�w�s�4W�-n��~zU�'��];��"�~]#P r�ݶ4{׈˝h�g�(�Y�6�5��b���CV�B ����5��^'�6�1�� �O��͒\a�4��D`H�ȸ�F��\��2S�X,?>۲�Ȓݾõ��A���h@U$QY�������� These rodents are social species and should be housed together, unless scientifically justified for individual housing. is recommended for principles of rabbit pen design. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) School Tunku Abdul Rahman University; Course Title LAW 1001; Uploaded By yannot. No. According to UK Home Office guidelines, the room temperature for mice should be 20–24°C (68–75°F) and kept as stable as possible . CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. Guide to the Care and Use of Experimental Animals, Volume 1 and 2, Canadian Council on Animal Care. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. Fax: (734) 936-3234 Ventilated cages were designed to prevent the accumulation of NH When possible (depending on the caging system used) individually housed mice should be provided housing that allows visual, auditory and olfactory contact with other mice. (Enclosures should allow for a minimum floor area of 250cm2 for a single housed mouse, a minimum floor area of 500cm2 for two mice and ensuring a minimum floor area of 60cm2 per additional adult mouse when mice are housed in larger groups.) To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). 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Management of Fighting Mice . Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design Debby Laukens, ... the genetic history of mutant mice is often ambiguous when mice are shared between institutions (Sellers et al. Follow procedures outlined in. The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. 3 0 obj However, attempts to assess the effectiveness of specific pathogen-free (SPF 1) housing, husbandry, and health care have been sparse. The . Nursing mothers or breeding pairs are kept in a quiet cage or tub with no wire floor. the draft guidelines for the housing of mice in scientific institutions. The IACUC acknowledges that some specialized genetically modified lines may require more than 2 adults and 1 litter in the breeding cage to facilitate adequate production. Not a departure. Based on data from Guidelines for the housing of Mice in Scientific Institutions, 2012, the consumption of mice feed range from 4-8 grams/day and water consumption 5-8 ml/day (Fawcett, 2013). The NC3Rs have led a data crowdsourcing project, which estimated the prevalence of aggression in UK facilities as approximately 15 in every 1,000 mice. If post-partum estrus is used in "standard" mouse cages, the first litter must be weaned by 21 days of age to prevent the presence of two litters in a cage, i.e. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. The same authors ( Smith et al. 2800 Plymouth Road Additional floor space may be required in order to ensure animal well-being. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. 8 Epizootic diarrhea of infant mice virus (EDIM) is commonly used as a generic name for all mouse rotaviruses. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. <> Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … Keyphrases. 8,9 Indeed, many studies have compared individual versus group housing of rodents under laboratory conditions. With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and g… Institutional Animal Care and Use Committee . Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. GUIDELINES FOR RATS AND MICE . The 'Guidelines for the Housing of Rabbits in Scientific Institutions ' (see Section 4.) The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). New arrival mice. No. New arrival mice. To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. <>>> • If scientifically justified in an approved IACUC protocol, mice may be individually housed in specific situations outlined in the IACUC protocol. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. the draft guidelines for the housing of mice in scientific institutions. GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS (2012) Cached. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. Purpose. The NACLAR Guidelines set out the responsibilities of animals for scientific purposes. 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. GUIDELINES FOR RATS AND MICE . This does not apply to: Littermates that have been cage mates since birth. The normal total cholesterol level is 26.0-82.4 mg/dl. This is Part 3.2 of the Code of Practice for the Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Mouse rotavirus (MRV) is a group A rotavirus that replicates in the villus epithelial cells of the small intestine. These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions … 䍫�����Q1Md:UdVDJ��*� <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Title: Guidelines for the Housing of Rats in Scientific Institutions Author: NSW Department of Primary Industries Created Date: 1/24/2008 1:20:25 PM The plant extract reduced castor oil-induced gastrointestinal movement of charcoal meal significantly at 200 and 400 mg/kg doses compared with the negative control in a dose-dependent manner.The highest effect was produced by 400 mg/kg dose of the extract, which was comparable to the effect of … Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 … The design of animal housing should facilitate well being of the animals, meet research requirements, minimise experimental variables, and isolate the animals from wide variations in temperature and humidity and from vibration and sources of loud noise. endobj Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. Many murine pathogens are known to result in immune perturbations that can affect research outcomes (Hsu, et al., 2016; Macy, et al., 2011). endobj Do not recombine adult male mice (older than 5 weeks) that have been separated. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. cage ("standard" rat cage). Guideline No. HOUSING AND CARE preprint issued by THE ROYAL SOCIETY 6 Carlton House Terrace, London SWlY SAG and UNIVERSITIES FEDERATION FOR ANIMAL WELFARE 8 Hamilton Close, South … The CCAC guidelines: Mice provides information for investigators, animal care committees, facility manag- Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. When breeding, no more than 2 adults and 1 litter, regardless of the size of the litter, will be allowed in a 75 square inch ("standard" mouse) cage. Group-house weaned males with their littermates only. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … Many experimental approaches require housing rodents in individual cages, including in epilepsy research. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. Guidelines for Transgenic Research. Basic requirements for good rodent housing and husbandry are given in the table below. )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. 4 0 obj Forty-one percent of institutions reported housing 0-20% of their mice under conventional conditions. Exceptions to this guideline require prior IACUC approval. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. Wean pups by 21 days of age in either breeding scheme. Ann Arbor, MI 48109 GUIDANCE & OVERSIGHT Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. The authors concluded that housing mice at twice Guide-recommended densities has no deleterious impact on any of the parameters assessed. Severe wounds (e.g., those involving the genitals or limbs that compromise normal function, significant damage to the epidermis, or significant morbidity) must be euthanized promptly following assessment by ULAM veterinary personnel. Guidelines for Transgenic Research. The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. However, rats and mice are social animals; and individual housing constitutes a stressful situation. SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. It is suggested that the housing of laboratory rodents should be improved by the use of … Some strains are more aggressive than others, and fight regardless of the age at combination. Canadian Council on Animal Care. Phone: (734) 763-8028 Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. guideline housing mouse scientific institution Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. It is suggested that the housing of laboratory rodents … Email: [email protected]. if housed in standard #3 rat caging. %���� Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . Use a clean cage when combining males from different litters to prevent territorial behavior. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Abstract. This code is made under the Prevention of Cruelty to Animals Act 1986 and applies to all institutions breeding and using such animals for research, testing and teaching.. 412 Victor Vaughan Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. 11 However, the observed effects can depend on the sex and strain of the animals on the one hand, and on the cage and laboratory environment on the other hand. Ann Arbor, MI 48109 … Housing in stable, compatible groups - it is important to take into account sex, age, reproductive condition, familiarity, prior group housing experience when grouping the animals. The Republic of Singapore, also referred to as the Garden City, is claimed as the world's only island city-state. Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. Males from different litters can be combined within seven days of weaning, only if age difference is 7 days apart or less. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Delayed weaning (weaning at >21 days) requires prior IACUC approval. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. A.L Hargreaves. The Code of Practice for Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits applies throughout Victoria. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are housed in static cages for the study duration. In all cases, cages should be regularly monitored to ensure the well-being of the neonates (e.g., size, age, and activity level of litter), as well as characteristics of the cage environment and colony breeding performance. Code of Practice for the Housing and Care of Laboratory Mice Rats Guinea Pigs. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … 1 0 obj endobj The need for genotyping leads to the requirement to identify very young mice, thus creating specific problems (...) Capture and transport of cephalopods Present On 1 January 2013, research using cephalopods and octopus), including hatched juveniles and adults, became regulated within the Directive 2010/63/EU. Deviation from Guide should statement according to IACUC-approved: Scientific justification Appendix A of the Council of Europe (2009) in the Convention for the protection of vertebrate animals used for experimental and other scientific … Unit for Laboratory Animal Medicine (ULAM) 3.5. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). <> Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). This does not apply to: Littermates that have been cage mates since birth. The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. This preview shows page 45 - 48 out of 83 pages. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. Introduction These guidelines are designed for everyone involved in the holding and care of dogs in scientific institutions. 2012). 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or [email protected]. Code of practice for the housing and care of animals bred, supplied or used for scientific purposes (full version): print-ready Ref: ISBN 9781474112390 , 19111403 12/14 44389 PDF , 3.42MB , 227 pages Fax: (734) 936-3235 Q�N���e9k��DjϋY�O��� �!�=� stream in. Deviation from Guide should statement according to a locally established performance standard. Follow housing densities for the type of caging used. Canadian Council on Animal Care. Email: [email protected], HUSBANDRY & VETERINARY CARE ANZCCART 2000 Animal Care & Use Office (ACUO) Guidelines on the Care and Use of Animals for Scientific Purposes, which has been developed by theNational Advisory Committee For Laboratory Animal Research (NACLAR), is a national guide which establishes the best practices in the use and care of animals for scientific purposes. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 %PDF-1.5 An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. OpenURL . ��~[Q\ �]*{��~��A���WFŀ�̥-��g|��ۢ����j�i�a,}�w�s�4W�-n��~zU�'��];��"�~]#P r�ݶ4{׈˝h�g�(�Y�6�5��b���CV�B ����5��^'�6�1�� �O��͒\a�4��D`H�ȸ�F��\��2S�X,?>۲�Ȓݾõ��A���h@U$QY�������� These rodents are social species and should be housed together, unless scientifically justified for individual housing. is recommended for principles of rabbit pen design. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) School Tunku Abdul Rahman University; Course Title LAW 1001; Uploaded By yannot. No. According to UK Home Office guidelines, the room temperature for mice should be 20–24°C (68–75°F) and kept as stable as possible . CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. Guide to the Care and Use of Experimental Animals, Volume 1 and 2, Canadian Council on Animal Care. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. Fax: (734) 936-3234 Ventilated cages were designed to prevent the accumulation of NH When possible (depending on the caging system used) individually housed mice should be provided housing that allows visual, auditory and olfactory contact with other mice. (Enclosures should allow for a minimum floor area of 250cm2 for a single housed mouse, a minimum floor area of 500cm2 for two mice and ensuring a minimum floor area of 60cm2 per additional adult mouse when mice are housed in larger groups.) To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). Trio breeding SOP with local performance measures to house mice in solid bottom cages with 71 in2 floor space. Authorization for Animal Housing and Special Services Costs. Tumour given to mice infected with human-pathogenic or zoonotic agents or genetically modified mice that har-bour receptors for human pathogens. Approved in the following conditions: Separate male before parturition if caging is < 212 square,! Mothers or breeding pairs are kept in a 100 sq litters can bred! Used are compliant with the 2020 guidelines mice are social species and should be (... Rodents are social animals ; and individual housing must be approved in following. Published scientific information and practices employed in New South Wales, Australia methods already used! Can serve as hiding places and/or for climbing Littermates that have been cage mates since birth approaches require rodents! The effectiveness of specific pathogen-free ( SPF 1 ) housing, husbandry, and fight regardless of normal... 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